Purpose
There appears to be controversy regarding differing patient and physician perceptions
of adverse effects (AEs) in the treatment of Dupuytren disease with collagenase clostridium
histolyticum (CCH). The aim of this study was to compare the number, type, and severity
of AEs perceived and reported by patients and by their physician
Methods
To assess AEs following CCH injection in a standardized way, patients were given a
list of predefined complications and asked to rate their severity on a 4-point Likert
scale ranging from 1 (serious) to 4 (insignificant).
Results
Eighty-five patients were included. Patients reported fewer AEs than their physician
(mean, 1.48 vs 2.18). There was no agreement between physician- and patient-reported
AEs except for skin lacerations, which showed fair agreement (κ = 0.257).
Conclusions
Patients and physicians differ in their evaluation of AEs due to CCH treatment in
Dupuytren disease. A fair level of agreement was observed for skin lacerations.
Clinical relevance
Greater consensus is needed when defining AEs associated with CCH in the treatment
of Dupuytren disease.
Key words
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Article info
Publication history
Published online: June 17, 2022
Accepted:
April 22,
2022
Received:
July 15,
2021
Publication stage
In Press Corrected ProofFootnotes
No benefits in any form have been received or will be received related directly or indirectly to the subject of this article.
Identification
Copyright
© 2022 by the American Society for Surgery of the Hand. All rights reserved.
