Case Repository| Volume 48, ISSUE 2, P200.e1-200.e3, February 2023

Download started.


A Rare Case of Rosai-Dorfman Disease Affecting the Brachial Plexus: A Case Report

Published:January 20, 2022DOI:
      Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease is a rare but well-established entity, commonly affecting the lymph nodes of the head and neck. Extranodal presentation, affecting the central nervous system, eye orbit, kidneys, testis, bones, upper respiratory tract, lungs, thyroid, small intestine, and peritoneum, has been reported. We present a case of a rare presentation of Rosai-Dorfman disease affecting the brachial plexus.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Hand Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Rosai J.
        • Dorfman R.F.
        Sinus histiocytosis with massive lymphadenopathy.
        Arch Pathol. 1969; 87: 63-70
        • Parekh A.
        • Osmani F.
        • Aardsma N.
        • Groth J.
        • Gonzalez M.
        Osseous Rosai-Dorfman disease presenting as a solitary lesion of the distal radius.
        J Hand Surg Am. 2019; 44: 70.e1-70.e5
        • Potts C.A.
        • Bozeman A.P.
        • Walker A.N.
        • Floyd III, W.E.
        Cutaneous Rosai-Dorfman disease of the forearm: case report.
        J Hand Surg Am. 2008; 33: 1409-1413
        • Mantilla J.G.
        • Goldberg-Stein S.
        • Wang Y.
        Extranodal Rosai-Dorfman disease: clinicopathologic series of 10 patients with radiologic correlation and review of the literature.
        Am J Clinical Pathol. 2016; 145: 211-221
        • Ottaviano G.
        • Doro D.
        • Marioni G.
        • et al.
        Extranodal Rosai-Dorfman disease: involvement of eye, nose and trachea.
        Acta Otolaryngol. 2006; 126: 657-660
        • Goyal G.
        • Ravindran A.
        • Young J.R.
        • et al.
        Mayo Clinic Histiocytosis Working Group. Clinicopathological features, treatment approaches, and outcomes in Rosai-Dorfman disease.
        Haematologica. 2020; 105: 348-357
        • Eisen R.N.
        • Buckley P.J.
        • Rosai J.
        Immunophenotypic characterization of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).
        Semin Diagn Pathol. 1990; 7: 74-82
        • Duggins A.J.
        • McLeod J.G.
        • Pollard J.D.
        • et al.
        Spinal root and plexus hypertrophy in chronic inflammatory demyelinating polyneuropathy.
        Brain. 1999; 122: 1383-1390
        • Pacelli J.
        • Whitaker C.H.
        Brachial plexopathy due to malignant peripheral nerve sheath tumor in neurofibromatosis type 1: case report and subject review.
        Muscle Nerve. 2006; 33: 697-700