Advertisement
Editor's choice| Volume 44, ISSUE 4, P304-310, April 2019

Download started.

Ok

Comparison of Ultrasound-Guided Versus Landmark-Based Corticosteroid Injection for Carpal Tunnel Syndrome: A Prospective Randomized Trial

      Purpose

      Although a local corticosteroid injection for carpal tunnel syndrome (CTS) is frequently performed by palpation using anatomical landmarks, ultrasound (US) allows physicians to visualize and confirm placement of the injectate close to the median nerve, possibly improving the efficacy of the injection. The aim of this study was to compare the effectiveness and complications of US-guided steroid injections with landmark-based injections for CTS.

      Methods

      A total of 102 patients with CTS were randomized into 2 groups: landmark-based injection and US-guided injection. The response to treatment, including grip strength and the Boston Carpal Tunnel Questionnaires (BCTQ) was assessed at baseline and at 4, 12, and 24 weeks after the injection.

      Results

      The BCTQ symptom and function scores were similar in the 2 groups throughout the 24-week follow-up period, with the exception of significantly lower (better) symptom scores at 4-week follow-up in the US-guided injection group. The grip strength was similar in the 2 groups throughout the 24-week follow-up period. After 24 weeks, 12 patients (24%) in the landmark-based injection group and 9 patients (18%) in the US-guided injection group had undergone carpal tunnel surgery. Symptoms of median nerve irritation were more likely to occur in patients with landmark-based injections (14%) than in those with US-guided injection (2%).

      Conclusions

      A US-guided steroid injection for CTS produces pain and functional results similar to those of landmark-based injection.

      Type of study/level of evidence

      Therapeutic I.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Hand Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Roh Y.H.
        • Chung M.S.
        • Baek G.H.
        • Lee Y.H.
        • Rhee S.H.
        • Gong H.S.
        Incidence of clinically diagnosed and surgically treated carpal tunnel syndrome in Korea.
        J Hand Surg Am. 2010; 35: 1410-1417
        • Andreu J.L.
        • Ly-Pen D.
        • Millán I.
        • de Blas G.
        • Sánchez-Olaso A.
        Local injection versus surgery in carpal tunnel syndrome: neurophysiologic outcomes of a randomized clinical trial.
        Clin Neurophysiol. 2014; 125: 1479-1484
        • Graham B.
        • Peljovich A.E.
        • Afra R.
        • et al.
        The American Academy of Orthopaedic Surgeons Evidence-Based Clinical Practice Guideline: on management of carpal tunnel syndrome.
        J Bone Joint Surg Am. 2016; 98: 1750-1754
        • Meys V.
        • Thissen S.
        • Rozeman S.
        • Bekman R.
        Prognostic factors in carpal tunnel syndrome treated with a corticosteroid injection.
        Muscle Nerve. 2011; 44: 763-768
        • Roh Y.H.
        • Noh J.H.
        • Gong H.S.
        • Baek G.H.
        Comparative study on the effectiveness of a corticosteroid injection for carpal tunnel syndrome in patients with and without Raynaud's phenomenon.
        Bone Joint J. 2017; 99-B: 1637-1642
        • Roh Y.H.
        • Lee B.K.
        • Baek J.R.
        • et al.
        Effect of metabolic syndrome on the outcome of corticosteroid injection for carpal tunnel syndrome.
        J Hand Surg Eur Vol. 2016; 41: 963-969
        • Blazar P.E.
        • Floyd IV, W.E.
        • Han C.H.
        • Rozental T.D.
        • Earp B.E.
        Prognostic indicators for recurrent symptoms after a single corticosteroid injection for carpal tunnel syndrome.
        J Bone Joint Surg Am. 2015; 97: 1563-1570
        • Racasan O.
        • Dubert T.
        The safest location for steroid injection in the treatment of carpal tunnel syndrome.
        J Hand Surg Br. 2005; 30: 412-414
        • Kim D.H.
        • Jang J.E.
        • Park B.K.
        Anatomical basis of ulnar approach in carpal tunnel injection.
        Pain Physician. 2013; 16: E191-E198
        • Evers S.
        • Bryan A.J.
        • Sanders T.L.
        • Selles R.W.
        • Gelfman R.
        • Amadia P.C.
        Effectiveness of ultrasound-guided compared to blind steroid injections in the treatment of carpal tunnel syndrome.
        Arthritis Care Res (Hoboken). 2017; 69: 1060-1065
        • Teh J.
        • Vlychou M.
        Ultrasound-guided interventional procedures of the wrist and hand.
        Eur Radiol. 2009; 19: 1002-1010
        • Evers S.
        • Bryan A.J.
        • Sanders T.L.
        • Gunderson T.
        • Gelfman R.
        • Amadio P.C.
        Influence of injection volume on rate of subsequent intervention in carpal tunnel syndrome over 1-year follow-up.
        J Hand Surg Am. 2018; 43: 537-544
        • Ustun N.
        • Tok F.
        • Yagz A.E.
        • et al.
        Ultrasound-guided vs. blind steroid injections in carpal tunnel syndrome: a single-blind randomized prospective study.
        Am J Phys Med Rehabil. 2013; 92: 999-1004
        • Chen P.C.
        • Wang L.Y.
        • Pong Y.P.
        • Hsin Y.J.
        • Liaw M.Y.
        • Chiang C.W.
        Effectiveness of ultrasound-guided vs direct approach corticosteroid injections for carpal tunnel syndrome: a double-blind randomized controlled trial.
        J Rehabil Med. 2018; 50: 200-208
        • Bland J.D.
        A neurophysiological grading scale for carpal tunnel syndrome.
        Muscle Nerve. 2000; 23: 1280-1283
        • McConnell J.R.
        • Bush D.C.
        Intraneural steroid injection as a complication in the management of carpal tunnel syndrome. A report of three cases.
        Clin Orthop Relat Res. 1990; 250: 181-184
        • Frederick H.A.
        • Carter P.R.
        • Littler J.W.
        Injection injuries to the median and ulnar nerves at the wrist.
        J Hand Surg Am. 1992; 17: 645-647
        • Hudson A.R.
        Nerve injection injuries.
        Clin Plast Surg. 1984; 11: 27-30
        • Mackinnon S.E.
        • Hudson A.R.
        • Gentili F.
        • Kline D.O.
        • Hunter D.
        Peripheral nerve injection injury with steroid agents.
        Plast Reconstr Surg. 1982; 69: 482-490
        • Kasten S.J.
        • Louis D.S.
        Carpal tunnel syndrome: a case of median nerve injection injury and a safe and effective method for injecting the carpal tunnel.
        J Fam Pract. 1996; 43: 79-82
        • Kim H.J.
        • Park S.H.
        Median nerve injuries caused by carpal tunnel injections.
        Korean J Pain. 2014; 27: 112-117
        • Levine D.W.
        • Simmons B.P.
        • Koris M.J.
        • et al.
        A self-administered questionnaire for the assessment of severity of symptoms and functional status in carpal tunnel syndrome.
        J Bone Joint Surg Am. 1993; 75: 1585-1592
        • Berger M.
        • Vermeulen M.
        • Koelman J.H.
        • van Schaik I.N.
        • Roos Y.B.
        The long-term follow-up of treatment with corticosteroid injections in patients with carpal tunnel syndrome. When are multiple injections indicated?.
        J Hand Surg Eur Vol. 2013; 38: 634-639
        • Ly-Pen D.
        • Andréu J.L.
        • Millán I.
        • de Blas G.
        • Sánchez-Olaso A.
        Comparison of surgical decompression and local steroid injection in the treatment of carpal tunnel syndrome: 2-year clinical results from a randomized trial.
        Rheumatology (Oxford). 2012; 51: 1447-1454
        • Armstrong T.
        • Devor W.
        • Borschel L.
        • Contreras R.
        Intracarpal steroid injection is safe and effective for short-term management of carpal tunnel syndrome.
        Muscle Nerve. 2004; 29: 82-88
        • Padua L.
        • Padua R.
        • Aprile I.
        • et al.
        Multiperspective follow-up of untreated carpal tunnel syndrome: a multicenter study.
        Neurology. 2001; 56: 1459-1466
        • Dammers J.W.
        • Veering M.M.
        • Vermeulen M.
        Injection with methylprednisolone proximal to the carpal tunnel: randomised double blind trial.
        BMJ. 1999; 319: 884-886
        • Lee J.Y.
        • Park Y.
        • Park K.D.
        • Lee J.K.
        • Lim O.K.
        Effectiveness of ultrasound-guided carpal tunnel injection using in-plane ulnar approach: a prospective, randomized, single-blinded study.
        Medicine (Baltimore). 2014; 93: e350
        • Eslamian F.
        • Eftekharsadat B.
        • Babaei-Ghazani A.
        • Jahanjoo F.
        • Zeinali M.
        A randomized prospective comparison of ultrasound-guided and landmark-guided steroid injections for carpal tunnel syndrome.
        J Clin Neurophysiol. 2017; 34: 107-113
        • Ozturk K.
        • Esenyel C.Z.
        • Sonmez M.
        • Esenyel M.
        • Kahraman S.
        • Senel B.
        Comparison of carpal tunnel injection techniques: a cadaver study.
        Scand J Plast Reconstr Surg Hand Surg. 2008; 42: 300-304
        • Habib G.S.
        • Badarny S.
        • Rawashdeh H.
        A novel approach of local corticosteroid injection for the treatment of carpal tunnel syndrome.
        Clin Rheumatol. 2006; 25: 338-340
        • Kaile E.
        • Bland J.D.P.
        Safety of corticosteroid injection for carpal tunnel syndrome.
        J Hand Surg Eur Vol. 2018; 43: 296-302
        • Peters-Veluthamaningal C.
        • Winters J.C.
        • Groenier K.H.
        • Meyboom-de Jong B.
        Randomised controlled trial of local corticosteroid injections for carpal tunnel syndrome in general practice.
        BMC Fam Pract. 2010; 11: 54