Advertisement
Scientific article| Volume 40, ISSUE 5, P987-992, May 2015

Download started.

Ok

Preliminary Results of Recurrent Cubital Tunnel Syndrome Treated With Neurolysis and Porcine Extracellular Matrix Nerve Wrap

      Purpose

      To evaluate the clinical results of revision neurolysis and wrapping with porcine extracellular matrix (AxoGuard Nerve Protector, AxoGen Inc., Alachua, FL) for cubital tunnel syndrome after one previous surgical decompression.

      Methods

      Twelve patients with recurrent cubital tunnel syndrome were treated with decompression, porcine extracellular matrix nerve wrap, and minimal medial epicondylectomy (if not previously performed). The average follow-up period was 41 months (range, 24–61 mo). All patients had recurrent symptoms after having previously undergone one surgical decompression. The mean patient age was 45 years (range, 30–58 y). All patients were evaluated subjectively and objectively (pain, satisfaction, static 2-point discrimination, grip strength, and pinch strength).

      Results

      A significant improvement was demonstrated in postoperative pain levels (from 8.5 to 1.7), grip strength (from 41% to 86% of the unaffected side), and pinch strength (from 64% to 83% of the unaffected side). Static 2-point discrimination improved from an average 10.4 mm preoperatively to 7.6 mm postoperatively. Eleven of 12 patients demonstrated 2 mm or more improvement in 2-point discrimination postoperatively. There were no complications related to the use of the porcine extracellular matrix for nerve wrapping.

      Conclusions

      This study found that secondary decompression combined with porcine extracellular matrix nerve wrapping was an effective and safe treatment for patients with recurrent cubital tunnel syndrome.

      Type of study/level of evidence

      Therapeutic IV.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Hand Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bartels R.H.
        • Menovsky T.
        • Van Overbeeke J.J.
        • Verhagen W.I.
        Surgical management of ulnar nerve compression at the elbow: An analysis of the literature.
        J Neurosurg. 1998; 89: 722-777
        • Mowlavi A.
        • Andrews K.
        • Lille S.
        • et al.
        The management of cubital tunnel syndrome: A meta-analysis of clinical studies.
        Plast Reconstr Surg. 2000; 106: 327-334
        • Dellon A.L.
        Review of treatment results for ulnar nerve entrapment at the elbow.
        J Hand Surg Am. 1989; 14: 688-700
        • Broudy A.S.
        • Leffert R.D.
        • Smith R.J.
        Technical problems with ulnar nerve transposition at the elbow: findings and results of reoperation.
        J Hand Surg Am. 1978; 3: 85-89
        • Rogers M.R.
        • Bergfield T.G.
        • Aulicino P.L.
        The failed ulnar nerve transposition. Etiology and treatment.
        Clin Orthop Relat Res. 1991; : 193-200
        • Filippi R.
        • Charalampaki P.
        • Reisch R.
        • et al.
        Recurrent cubital tunnel syndrome. Etiology and treatment.
        Minim Invasive Neurosurg. 2001; 44: 197-201
        • Masear V.R.
        • Colgin S.
        The treatment of epineural scarring with allograft vein wrapping.
        Hand Clin. 1996; 12: 773-779
        • Xu J.
        • Sotereanos D.G.
        • Moller A.R.
        • et al.
        Nerve wrapping with vein grafts in a rat model: A safe technique for the treatment of recurrent chronic compressive neuropathy.
        J Reconstr Microsurg. 1998; 14: 323-328
        • Xu J.
        • Varitimidis S.E.
        • Fisher K.J.
        • et al.
        The effect of wrapping scarred nerves with autogenous vein graft to treat recurrent chronic nerve compression.
        J Hand Surg Am. 2000; 25: 93-103
        • Varitimidis S.E.
        • Riano F.
        • Sotereanos D.G.
        Recalcitrant post-surgical neuropathy of the ulnar nerve at the elbow: Treatment with autogenous saphenous vein wrapping.
        J Reconstr Microsurg. 2000; 16: 273-277
        • Vardakas D.G.
        • Varitmidis S.E.
        • Sotereanos D.G.
        Findings of exploration of a vein-wrapped ulnar nerve: Report of a case.
        J Hand Surg Am. 2001; 26: 60-63
        • Varitimidis S.E.
        • Vardakas D.G.
        • Goebel F.
        • et al.
        Treatment of recurrent compressive neuropathy of peripheral nerves in the upper extremity with an autologous vein insulator.
        J Hand Surg Am. 2001; 26: 296-302
        • Kokkalis Z.T.
        • Jain S.
        • Sotereanos D.G.
        Vein wrapping at cubital tunnel for ulnar nerve problems.
        J Shoulder Elbow Surg. 2010; 19: 91-97
        • Chou K.H.
        • Papadimitriou N.G.
        • Sarris I.
        • et al.
        Neovascularization and other histopathologic findings in an autogenous saphenous vein wrap used for recalcitrant carpal tunnel syndrome: A case report.
        J Hand Surg Am. 2003; 28: 262-266
        • Jones N.F.
        Treatment of chronic pain by ‘‘wrapping’’ intact nerves with pedicle and free flaps.
        Hand Clin. 1996; 12: 765-772
        • Jones N.F.
        • Shaw W.W.
        • Katz R.G.
        • et al.
        Circumferential wrapping of a flap around a scarred peripheral nerve for salvage of end-stage traction neuritis.
        J Hand Surg Am. 1997; 22: 527-535
        • Kokkalis Z.T.
        • Pu C.
        • Small G.A.
        • et al.
        Assessment of processed porcine extracellular matrix as a protective barrier in a rabbit nerve wrap model.
        J Reconstr Microsurg. 2011; 27: 19-28
        • Ambro B.T.
        • Zimmerman J.
        • Rosenthal M.
        • et al.
        Nasal septal perforation repair with porcine small intestinal submucosa.
        Arch Facial Plast Surg. 2003; 5: 528-529
        • Franklin Jr., M.E.
        • Gonzalez Jr., J.J.
        • Glass J.L.
        Use of porcine small intestinal submucosa as a prosthetic device for laparoscopic repair of hernias in contaminated fields: 2-year follow-up.
        Hernia. 2004; 8: 186-189
        • Kini S.
        • Gagner M.
        • de Csepel J.
        • et al.
        A biodegradeable membrane from porcine intestinal submucosa to reinforce the gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass: preliminary report.
        Obes Surg. 2001; 11: 469-473
        • Mantovani F.
        • Trinchieri A.
        • Castelnuovo C.
        • et al.
        Reconstructive urethroplasty using porcine acellular matrix.
        Eur Urol. 2003; 44: 600-602
        • Mostow E.N.
        • Haraway G.D.
        • Dalsing M.
        • et al.
        Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial.
        J Vasc Surg. 2005; 41: 837-843
        • Rutner A.B.
        • Levine S.R.
        • Schmaelzle J.F.
        Processed porcine small intestine submucosa as a graft material for pubovaginal slings: durability and results.
        Urology. 2003; 62: 805-809
        • Gobel F.
        • Musgrave D.S.
        • Vardakas D.G.
        • Vogt M.T.
        • Sotereanos D.G.
        Minimal medial epicondylectomy and decompression for cubital tunnel syndrome.
        Clin Orthop Relat Res. 2001; : 228-236
        • Dellon A.L.
        Techniques for successful management of ulnar nerve entrapment at the elbow.
        Neurosurg Clin N Am. 1991; 2: 57-73
        • Gelberman R.H.
        • Eaton R.G.
        • Urbaniak J.R.
        Peripheral nerve compression.
        Instr Course Lect. 1994; 43: 31-53
        • Antoniadis G.
        • Richter H.P.
        Pain after surgery for ulnar neuropathy at the elbow: A continuing challenge.
        Neurosurgery. 1997; 41: 585-589
        • Gabel G.T.
        • Amadio P.C.
        Reoperation for failed decompression of the ulnar nerve in the region of the elbow.
        J Bone Joint Surg Am. 1990; 72: 213-219
        • Bartels R.H.
        • Grotenhuis J.A.
        Anterior submuscular transposition of the ulnar nerve for post-operative focal neuropathy at the elbow.
        J Bone Joint Surg Br. 2004; 86: 998-1001
        • Caputo A.E.
        • Watson H.K.
        Subcutaneous anterior transposition of the ulnar nerve for failed decompression of cubital tunnel syndrome.
        J Hand Surg Am. 2000; 25: 544-551
        • Vogel R.B.
        • Nossaman B.C.
        • Rayan G.M.
        Revision anterior submuscular transposition of the ulnar nerve for failed subcutaneous transposition.
        Br J Plast Surg. 2004; 57: 311-316