Acellular nerve allograft (ANA) processing removes Schwann cells (SCs) and vasculature
which may contribute to reduced nerve regeneration in ANAs compared to autografts.
Addition of SCs or vascular endothelial growth factor (VEGF) may improve the regenerative
microenvironment and therefore, facilitate nerve regeneration.
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References
- VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy.J Anat. 2000; 197: 591-605
- Schwann cells seeded in acellular nerve grafts improve functional recovery.Muscle Nerve. 2014; 49: 267-276
- Acellular nerve allografts in peripheral nerve regeneration: a comparative study.Muscle Nerve. 2011; 44: 221-234
- Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence.Exp Neurol. 2013; 247: 165-177
- Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts.Brain Res. 1999; 846: 219-228
Article info
Publication history
Paper 16
Footnotes
Clinical Paper Session 02: Nerve Repair/Regeneration
Friday, September 19, 2014 • 8:59–9:06 AM
Category: Treatment, Basic Science
Keyword: Nerve
Identification
Copyright
© 2014 Published by Elsevier Inc.
