Acellular nerve allograft (ANA) processing removes Schwann cells (SCs) and vasculature which may contribute to reduced nerve regeneration in ANAs compared to autografts. Addition of SCs or vascular endothelial growth factor (VEGF) may improve the regenerative microenvironment and therefore, facilitate nerve regeneration.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Hand Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy.J Anat. 2000; 197: 591-605
- Schwann cells seeded in acellular nerve grafts improve functional recovery.Muscle Nerve. 2014; 49: 267-276
- Acellular nerve allografts in peripheral nerve regeneration: a comparative study.Muscle Nerve. 2011; 44: 221-234
- Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence.Exp Neurol. 2013; 247: 165-177
- Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts.Brain Res. 1999; 846: 219-228
Clinical Paper Session 02: Nerve Repair/Regeneration
Friday, September 19, 2014 • 8:59–9:06 AM
Category: Treatment, Basic Science
© 2014 Published by Elsevier Inc.