Severe nerve crush injury produces damage indistinguishable from that of a severed
nerve with complete loss of function. And yet some crush injuries show amazing potential
for recovery while others do not. We hypothesized that a crush injuries differ in
the extent of damage to myelin and neurons and must leave a subset of neurons preserved
to support functional improvement. Perhaps it is these intact, partially injured neurons
which could be targeted for pharmacologic diagnostic testing. In such a case, compounds
used to stabilize partially injured neurons could be used diagnostically to prove
the existence of intact fibers even in the severest of crush injuries.
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References
- Sustained-release fampridine (4-aminopyridine) in multiple sclerosis: efficacy and impact on motor function.Drugs R D. 2013; 13: 171-181
- Pharmacokinetics and pharmacodynamics of 4-aminopyridine in anesthetized dogs.J Pharmacol Exp Ther. 1983; 225: 351-354
Article info
Publication history
Paper 15
Footnotes
Clinical Paper Session 02: Nerve Repair/Regeneration
Friday, September 19, 2014 • 8:52–8:59 AM
Category: Evaluation/Diagnosis, Prognosis/Outcomes, Patient Education, Anatomy, Basic Science
Keyword: Hand and Wrist, Elbow and Forearm, Shoulder and Arm, Nerve, Diseases and Disorders, General Principles
Identification
Copyright
© 2014 Published by Elsevier Inc.
