Abstract| Volume 39, ISSUE 9, SUPPLEMENT , e12, September 2014

A Pharmacologic Test to Establish Continuity and Function in the Crush-Injured Nerve

N/A - Not a Clinical Study
      Severe nerve crush injury produces damage indistinguishable from that of a severed nerve with complete loss of function. And yet some crush injuries show amazing potential for recovery while others do not. We hypothesized that a crush injuries differ in the extent of damage to myelin and neurons and must leave a subset of neurons preserved to support functional improvement. Perhaps it is these intact, partially injured neurons which could be targeted for pharmacologic diagnostic testing. In such a case, compounds used to stabilize partially injured neurons could be used diagnostically to prove the existence of intact fibers even in the severest of crush injuries.
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