The molecular and cellular signalling events responsible for human tendon adhesion formation are unclear. Prior in vitro studies of human tenocytes have demonstrated tenocyte ‘dedifferentiation’ (1), as seen by change in shape (from elongated to round) and extracellular matrix production with growth in low-density culture. Correspondingly, we hypothesized that adhesion formation post-tendon injury and repair represents, in actuality, the tenocyte dedifferentiated state.
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- In vitro two-dimensional and three-dimensional tenocyte culture for tendon tissue engineering.J Tissue Eng Regen Med. 2013; (Aug. 29 [Epub ahead of print])
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Thursday, September 18, 2014 • 2:29–2:34 PM
Category: Treatment, Prognosis/Outcomes, Basic Science
Keyword: Hand and Wrist, Diseases and Disorders, General Principles
© 2014 Published by Elsevier Inc.