The molecular and cellular signalling events responsible for human tendon adhesion
formation are unclear. Prior in vitro studies of human tenocytes have demonstrated
tenocyte ‘dedifferentiation’ (1), as seen by change in shape (from elongated to round)
and extracellular matrix production with growth in low-density culture. Correspondingly,
we hypothesized that adhesion formation post-tendon injury and repair represents,
in actuality, the tenocyte dedifferentiated state.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Hand SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Phenotypic drift in human tenocyte culture.Tissue Eng. 2006; 12: 1843-1849
- In vitro two-dimensional and three-dimensional tenocyte culture for tendon tissue engineering.J Tissue Eng Regen Med. 2013; (Aug. 29 [Epub ahead of print])
- Determination of GTP loading on Rho.Methods Enzymol. 2000; 325: 264-272
- Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.Am J Physiol Cell Physiol. 2010; 298: C749-C763
Article info
Publication history
Paper 03
Footnotes
Best Papers
Thursday, September 18, 2014 • 2:29–2:34 PM
Category: Treatment, Prognosis/Outcomes, Basic Science
Keyword: Hand and Wrist, Diseases and Disorders, General Principles
Identification
Copyright
© 2014 Published by Elsevier Inc.
