Abstract| Volume 39, ISSUE 9, SUPPLEMENT , e4, September 2014

Download started.


Human Tenocyte Differentiation Drives Adhesion Formation

N/A - Not a clinical study
      The molecular and cellular signalling events responsible for human tendon adhesion formation are unclear. Prior in vitro studies of human tenocytes have demonstrated tenocyte ‘dedifferentiation’ (1), as seen by change in shape (from elongated to round) and extracellular matrix production with growth in low-density culture. Correspondingly, we hypothesized that adhesion formation post-tendon injury and repair represents, in actuality, the tenocyte dedifferentiated state.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of Hand Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Yao L.
        • Bestwick C.S.
        • Bestwick L.A.
        • Maffulli N.
        • Aspden R.M.
        Phenotypic drift in human tenocyte culture.
        Tissue Eng. 2006; 12: 1843-1849
        • Qiu Y.
        • Wang X.
        • Zhang Y.
        • et al.
        In vitro two-dimensional and three-dimensional tenocyte culture for tendon tissue engineering.
        J Tissue Eng Regen Med. 2013; (Aug. 29 [Epub ahead of print])
        • Ren X.D.
        • Schwartz M.A.
        Determination of GTP loading on Rho.
        Methods Enzymol. 2000; 325: 264-272
        • Pattabiraman P.P.
        • Rao P.V.
        Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
        Am J Physiol Cell Physiol. 2010; 298: C749-C763