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Glucosamine and Chondroitin Sulfate Treatment of Hand Osteoarthritis

      Osteoarthritis of the hand is a common degenerative musculoskeletal condition affecting the health-related quality of life of many adults. Despite the high prevalence of symptomatic hand osteoarthritis, the therapeutic options are limited, and the mainstay of pharmacological treatment includes short-term use of oral analgesic and anti-inflammatory medications.
      • Miller K.L.
      • Clegg D.O.
      Glucosamine and Chondroitin Sulfate.
      However, the well-recognized systemic toxicities with these medications limit their use.
      • Clegg D.O.
      • Reda D.J.
      • Harris C.L.
      • et al.
      Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
      Recent public interest in alternative treatments for osteoarthritis has resulted from the limitations of conventional medications and the desire to decelerate the degenerative process.
      • Wandel S.
      • Juni P.
      • Tendal B.
      • et al.
      Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis.
      Glucosamine and chondroitin sulfate (CS) are among the most popular nonprescription nutriceutical products in the United States and are widely promoted by manufacturers to have remarkable chondroprotective benefits. This article aims to review the best available evidence to facilitate an evidence-based discussion with patients regarding the efficacy and safety of these products in patients with osteoarthritis of the hand.
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