Osteoarthritis of the hand is a common degenerative musculoskeletal condition affecting the health-related quality of life of many adults. Despite the high prevalence of symptomatic hand osteoarthritis, the therapeutic options are limited, and the mainstay of pharmacological treatment includes short-term use of oral analgesic and anti-inflammatory medications.
1However, the well-recognized systemic toxicities with these medications limit their use.
- Miller K.L.
- Clegg D.O.
Glucosamine and Chondroitin Sulfate.
Rheum Dis Clin North Am. 2011; 37: 103-118
2Recent public interest in alternative treatments for osteoarthritis has resulted from the limitations of conventional medications and the desire to decelerate the degenerative process.
- Clegg D.O.
- Reda D.J.
- Harris C.L.
- et al.
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.
N Engl J Med. 2006; 354: 795-808
3Glucosamine and chondroitin sulfate (CS) are among the most popular nonprescription nutriceutical products in the United States and are widely promoted by manufacturers to have remarkable chondroprotective benefits. This article aims to review the best available evidence to facilitate an evidence-based discussion with patients regarding the efficacy and safety of these products in patients with osteoarthritis of the hand.
- Wandel S.
- Juni P.
- Tendal B.
- et al.
Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis.
BMJ. 2010; (341c4675)
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of Hand Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Glucosamine and Chondroitin Sulfate.Rheum Dis Clin North Am. 2011; 37: 103-118
- Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.N Engl J Med. 2006; 354: 795-808
- Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis.BMJ. 2010; (341c4675)
- Use of glucosamine and chondroitin sulfate in the management of osteoarthritis.J Am Acad Orthop Surg. 2001; 9: 71-78
- Anti-inflammatory activity of chondroitin sulfate.Osteoarthritis Cartilage. 1998; 6: 14-21
- Use of glucosamine and chondroitin in persons with osteoarthritis.PM R. 2012; 4: S110-S116
- A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis.Arthroscopy. 2009; 25: 86-94
- Active ingredient consistency of commercially available glucosamine sulfate products.J Rhematol. 2002; 29: 2407-2409
- Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.Arch Intern Med. 2003; 163: 1514-1522
- Glucosamine therapy for treating osteoarthritis.Cochrane Database Syst Rev. 2005; 2 (CD002946)
- The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis.Arthritis Rheum. 2008; 58: 3183-3191
- Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.JAMA. 2000; 283: 1469-1475
- Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis.Arthritis Rheum. 2011; 63: 3383-3391
- Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA.Osteoarthritis Cartilage. 1998; 6: 37-38
- Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.Lancet. 2001; 357: 251-256
Accepted: May 14, 2013
Received: March 9, 2013
No benefits in any form have been received or will be received related directly or indirectly to the subject of this article.
© 2013 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.