Abstract
Over a 4-year period 63 patients (75 hands) with Dupuytren's nodules were treated
with a series of injections with the steroid triamcinolone acetonide directly into
the area of disease. The purpose of this study was to determine whether intralesional
injections of triamcinolone acetonide could produce softening and flattening in nodules
of Dupuytren's disease as seen in the intralesional injections of hypertrophic scars
and keloids. After an average of 3.2 injections per nodule 97% of the hands showed
regression of disease as exhibited by a softening or flattening of the nodule(s).
Although some patients had complete resolution of the nodules, most experienced definite
but incomplete resolution of the nodules in the range of 60% to 80%. Although a few
patients did not experience recurrence or reactivation of the disease in the injected
nodules or development of new nodules, 50% of patients did experience reactivation
of disease in the nodules 1 to 3 years after the last injection, necessitating 1 or
more injections. The findings of this study indicate that the intralesional injection
of nodules of Dupuytren's disease with triamcinolone acetonide may modify the progression
of the disease. (J Hand Surg 2000;25A:1157-1162. Copyright © 2000 by the American
Society for Surgery of the Hand.)
Keywords
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References
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- The degradation of mature collagen: a laboratory study.Plast Reconstr Surg. 1967; 40: 89-91
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- The biochemistry of Dupuytren's disease.Hand Clin. 1999; 15: 35-42
- Proposed mode of action of cortico-steroids on the connective tissue.Nature. 1965; 206: 158-160
- Effects of triamcinolone on tendon healing and function: a laboratory study.Plast Reconstr Surg. 1971; 47: 471-482
- Nonoperative treatment of Dupuytren's disease.Hand Clin. 1999; 15: 97-107
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Article info
Publication history
Accepted:
June 19,
2000
Received:
January 5,
2000
Footnotes
*No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
**Reprint requests: Lynn D. Ketchum, MD, 5701 W 119th St, Suite 215, Overland Park, KS 66209-3721.
Identification
Copyright
© 2000 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
