Journal of Hand Surgery
Volume 37, Issue 2 , Pages 209-216 , February 2012

Cellular Apoptosis and Proliferation in the Middle and Late Intrasynovial Tendon Healing Periods

Received 6 July 2011 ,Accepted 25 October 2011.

References 

  1. Abrahamsson SO . Matrix metabolism and healing in the flexor tendon (Experimental studies on rabbit tendon) . Scand J Plast Reconstr Surg Hand Surg Suppl . 1991;23:1–51
  2. Sharma P , Maffulli N . Biology of tendon injury: healing, modeling and remodeling . J Musculoskelet Neuronal Interact . 2006;6:181–190
  3. Oshiro W , Lou J , Xing X , Tu Y , Manske PR . Flexor tendon healing in the rat: a histologic and gene expression study . J Hand Surg . 2003;28A:814–823
  4. James R , Kesturu G , Balian G , Chhabra AB . Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options . J Hand Surg . 2008;33A:102–112
  5. Lundgreen K , Lian OB , Engebretsen L , Scott A . Tenocyte apoptosis in the torn rotator cuff: a primary or secondary pathological event? . Br J Sports Med . 2011;45:1035–1039
  6. Lian Ø , Scott A , Engebretsen L , Bahr R , Duronio V , Khan K . Excessive apoptosis in patellar tendinopathy in athletes . Am J Sports Med . 2007;35:605–611
  7. Benson RT , McDonnell SM , Knowles HJ , Rees JL , Carr AJ , Hulley PA . Tendinopathy and tears of the rotator cuff are associated with hypoxia and apoptosis . J Bone Joint Surg . 2010;92B:448–453
  8. Yuan J , Murrell GA , Wei AQ , Wang MX . Apoptosis in rotator cuff tendinopathy . J Orthop Res . 2002;20:1372–1379
  9. Lui PP , Cheuk YC , Hung LK , Fu SC , Chan KM . Increased apoptosis at the late stage of tendon healing . Wound Repair Regen . 2007;15:702–707
  10. Wong JK , Lui YH , Kapacee Z , Kadler KE , Ferguson MW , McGrouther DA . The cellular biology of flexor tendon adhesion formation: an old problem in a new paradigm . Am J Pathol . 2009;175:1938–1951
  11. Wu YF , Chen CH , Cao Y , Avanessian B , Wang XT , Tang JB . Molecular events of cellular apoptosis and proliferation in the early tendon healing period . J Hand Surg . 2010;35A:2–10
  12. Farkas LG , Thomson HG , Martin R . Some practical notes on the anatomy of chicken toe for surgeon investigators . Plast Reconstr Surg . 1974;54:452–458
  13. Manske PR , Lesker PA , Bridwell K . Experimental studies in chickens on the initial nutrition of tendon grafts . J Hand Surg . 1979;4:565–575
  14. Peterson WW , Manske PR , Kain CC , Lesker PA . Effect of flexor sheath integrity on tendon gliding: a biomechanical and histologic study . J Orthop Res . 1986;4:458–465
  15. Cao Y , Chen CH , Wu YF , Xu XF , Xie RG , Tang JB . Digital oedema, adhesion formation and resistance to digital motion after primary flexor tendon repair . J Hand Surg . 2008;33E:745–752
  16. Fu SC , Hung LK , Lee YW , Mok TY , Chan KM . Tendon adhesion measured by a video-assisted gliding test in a chicken model . J Hand Surg . 2011;36E:40–47
  17. Losa M , Barzaghi RL , Mortini P , Franzin A , Mangili F , Terreni MR , et al.  Determination of the proliferation and apoptotic index in adrenocorticotropin-secreting pituitary tumors: comparison between micro- and macroadenomas . Am J Pathol . 2000;156:245–251
  18. Tanaka F , Kawano Y , Li M , Takata T , Miyahara R , Yanagihara K , et al.  Prognostic significance of apoptotic index in completely resected non–small-cell lung cancer . J Clin Oncol . 1999;17:2728–2736
  19. Rai NK , Suryabhan  , Ansari M , Kumar M , Shukla VK , Tripathi K . Effect of glycaemic control on apoptosis in diabetic wounds . J Wound Care . 2005;14:277–281
  20. Fiala JC . Reconstruct: a free editor for serial section microscopy . J Microsc . 2005;218:52–61
  21. Lin TW , Cardenas L , Soslowsky LJ . Biomechanics of tendon injury and repair . J Biomech . 2004;37:865–877
  22. Beredjiklian PK . Biologic aspects of flexor tendon laceration and repair . J Bone Joint Surg . 2003;85A:539–550
  23. Tang JB , Cao Y , Zhu B , Xin KQ , Wang XT , Liu PY . Adeno-associated virus-2-mediated bFGF gene transfer to digital flexor tendons significantly increases healing strength (An in vivo study) . J Bone Joint Surg . 2008;90A:1078–1089
  24. Thomopoulos S , Kim HM , Das R , Silva MJ , Sakiyama-Elbert S , Amiel D , et al.  The effects of exogenous basic fibroblast growth factor on intrasynovial flexor tendon healing in a canine model . J Bone Joint Surg . 2010;92A:2285–2293
  25. Gelberman RH , Thomopoulos S , Sakiyama-Elbert SE , Das R , Silva MJ . The early effects of sustained platelet-derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: an in vivo biomechanic study at 3 weeks in canines . J Hand Surg . 2007;32A:373–379
  26. Tang JB , Xie RG , Cao Y , Ke ZS , Xu Y . A2 pulley incision or one slip of the superficialis improves flexor tendon repairs . Clin Orthop Relat Res . 2007;456:121–127
  27. Xu Y , Tang JB . Effects of superficialis tendon repairs on lacerated profundus tendons within or proximal to the A2 pulley: an in vivo study in chickens . J Hand Surg . 2003;28A:994–1001
  28. Morley N , Rapp A , Dittmar H , Salter L , Gould D , Greulich KO , et al.  UVA-induced apoptosis studied by the new apo/necro-Comet-assay which distinguishes viable, apoptotic and necrotic cells . Mutagenesis . 2006;21:105–114
  29. Garrity MM , Burgart LJ , Riehle DL , Hill EM , Sebo TJ , Witzig T . Identifying and quantifying apoptosis: navigating technical pitfalls . Mod Pathol . 2003;16:389–394

 Supported by grants from the Health Bureau of Jiangsu Province and the Department of Hand Surgery, Nantong University, Natural Science Foundation of China (No 81030035).

 No benefits in any form have been received or will be received related directly or indirectly to the subject of this article.

PII: S0363-5023(11)01375-X

doi: 10.1016/j.jhsa.2011.10.049

Journal of Hand Surgery
Volume 37, Issue 2 , Pages 209-216 , February 2012