Journal of Hand Surgery
Volume 35, Issue 5 , Pages 791-796 , May 2010

Hyaluronan Modulates Proliferation and Migration of Rabbit Fibroblasts Derived From Flexor Tendon Epitenon and Endotenon

Received 30 November 2009 ,Accepted 8 February 2010.

References 

  1. Potenza AD. Prevention of adhesion to healing digital flexor tendons. JAMA. 1964;187:187–191
  2. Zhao C, Sun YL, Amadio PC, Tanaka T, Ettema AM, An KN. Surface treatment of flexor tendon autografts with carbodiimide-derivatized hyaluronic acid: an in vivo canine model. J Bone Joint Surg. 2006;88A:2181–2191
  3. Kitsis CK, Wade PJ, Krikler SJ, Parsons NK, Nicholls LK. Controlled active motion following primary flexor tendon repair: a prospective study over 9 years. J Hand Surg. 1998;23B:344–349
  4. Small JO, Brennen MD, Colville J. Early active mobilisation following flexor tendon repair in zone 2. J Hand Surg. 1989;14B:383–391
  5. Lister GD, Kleinert HE, Kutz JE, Atasoy E. Primary flexor tendon repair followed by immediate controlled mobilization. J Hand Surg. 1977;2:441–451
  6. Gelberman RH, Boyer MI, Brodt MD, Winters SC, Silva MJ. The effect of gap formation at the repair site on the strength and excursion of intrasynovial flexor tendons: an experimental study on the early stages of tendon-healing in dogs. J Bone Joint Surg. 1999;81A:975–982
  7. Zhao C, Amadio PC, Tanaka T, Kutsumi K, Tsubone T, Zobitz ME, et al. Effect of gap size on gliding resistance after flexor tendon repair. J Bone Joint Surg. 2004;86A:2482–2488
  8. Golash A, Kay A, Warner JG, Peck F, Watson JS, Lees VC. Efficacy of ADCON-T/N after primary flexor tendon repair in Zone II: a controlled clinical trial. J Hand Surg. 2003;28B:113–115
  9. Hanff G, Hagberg L. Prevention of restrictive adhesions with expanded polytetrafluoroethylene diffusible membrane following flexor tendon repair: an experimental study in rabbits. J Hand Surg. 1998;23A:658–664
  10. Cerovac S, Afoke A, Akali A, McGrouther DA. Early breaking strength of repaired flexor tendon treated with 5-fluorouracil. J Hand Surg. 2001;26B:220–223
  11. Karakurum G, Buyukbebeci O, Kalender M, Gulec A. Seprafilm interposition for preventing adhesion formation after tenolysis: an experimental study on the chicken flexor tendons. J Surg Res. 2003;113:195–200
  12. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999;7:79–89
  13. Wisniewski HG, Hua JC, Poppers DM, Naime D, Vilcek J, Cronstein BN. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. J Immunol. 1996;156:1609–1615
  14. Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997;242:27–33
  15. Amiel D, Ishizue K, Billings E, Wiig M, Vande Berg J, Akeson WH, et al. Hyaluronan in flexor tendon repair. J Hand Surg. 1989;14A:837–843
  16. St Onge R, Weiss C, Denlinger JL, Balazs EA. A preliminary assessment of Na-hyaluronate injection into “no man's land” for primary flexor tendon repair. Clin Orthop Relat Res. 1980;146:269–275
  17. Thomas SC, Jones LC, Hungerford DS. Hyaluronic acid and its effect on postoperative adhesions in the rabbit flexor tendon: a preliminary look. Clin Orthop Relat Res. 1986;206:281–289
  18. Hagberg L, Gerdin B. Sodium hyaluronate as an adjunct in adhesion prevention after flexor tendon surgery in rabbits. J Hand Surg. 1992;17A:935–941
  19. Tatari H, Skiak E, Destan H, Ulukuş C, Ozer E, Satoğlu S. Effect of hylan G-F 20 in Achilles' tendonitis: an experimental study in rats. Arch Phys Med Rehabil. 2004;85:1470–1474
  20. Yagishita K, Sekiya I, Sakaguchi Y, Shinomiya K, Muneta T. The effect of hyaluronan on tendon healing in rabbits. Arthroscopy. 2005;21:1330–1336
  21. Salti NI, Tuel RJ, Mass DP. Effect of hyaluronic acid on rabbit profundus flexor tendon healing in vitro. J Surg Res. 1993;55:411–415
  22. Hagberg L. Exogenous hyaluronate as an adjunct in the prevention of adhesions after flexor tendon surgery: a controlled clinical trial. J Hand Surg. 1992;17A:132–136
  23. Wiig M, Abrahamsson SO, Lundborg G. Tendon repair: cellular activities in rabbit deep flexor tendons and surrounding synovial sheaths and the effects of hyaluronan: an experimental study in vivo and in vitro. J Hand Surg. 1997;22A:818–825
  24. Meyers SA, Seaber AV, Glisson RR, Nunley JA. Effect of hyaluronic acid/chondroitin sulfate on healing of full-thickness tendon lacerations in rabbits. J Orthop Res. 1989;7:683–689
  25. de Wit T, de Putter D, Tra WM, Rakhorst HA, van Osch GJ, Hovius SE, et al. Auto-crosslinked hyaluronic acid gel accelerates healing of rabbit flexor tendons in vivo. J Orthop Res. 2009;27:408–415
  26. Underhill C. CD44: the hyaluronan receptor. J Cell Sci. 1992;103:293–298
  27. Gunthert U, Hofmann M, Rudy W, Reber S, Zoller M, Haussmann I, et al. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell. 1991;5;:65;:13–24
  28. Jalkanen S, Bargatze RF, de los Toyos J, Butcher EC. Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J Cell Biol. 1987;105:983–990
  29. Miyake K, Medina KL, Hayashi S, Ono S, Hamaoka T, Kincade PW. Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med. 1990;171:477–488
  30. Shimizu Y, Van Seventer GA, Siraganian R, Wahl L, Shaw S. Dual role of the CD44 molecule in T cell adhesion and activation. J Immunol. 1989;143:2457–2463
  31. Yamada T, Gotoh M, Nakama K, Mitsui Y, Higuchi F, Nagata K. Effects of hyaluronan on cell proliferation and mRNA expression of procollagens alpha 1 (I) and alpha 1 (III) in tendon-derived fibroblasts from patients with rotator cuff disease: an in vitro study. Am J Sports Med. 2007;35:1870–1876
  32. Nago M, Mitsui Y, Gotoh M, Nakama K, Shirachi I, Higuchi F, et al. Hyaluronan modulates cell proliferation and mRNA expression of adhesion-related procollagens and cytokines in glenohumeral synovial/capsular fibroblasts in adhesive capsulitis. J Orthop Res. Jan 7, 2010;Epub ahead of print. PMID: 20058278
  33. Gelberman RH, Amiel D, Harwood F. Genetic expression for type I procollagen in the early stages of flexor tendon healing. J Hand Surg. 1992;17A:551–558
  34. Russell JE, Manske PR. Collagen synthesis during primate flexor tendon repair in vitro. J Orthop Res. 1990;8:13–20
  35. Abrahamsson SO, Lundborg G, Lohmander LS. Restoration of the injured flexor tendon surface: a possible role for endotenon cells (A morphological study of the rabbit tendon in vivo). J Hand Surg. 1992;17B:553–560
  36. Ishii S, Umeda H. Role of tendon tissues in healing: a morphological study in vitro and in vivo. In:  Hunter JM editors. Tendon surgery in the hand. St. Louis: Mosby; 1987;p. 79–85
  37. Mitsui Y, Gotoh M, Nakama K, Yamada T, Higuchi F, Nagata K. Hyaluronic acid inhibits mRNA expression of proinflammatory cytokines and cyclooxygenase-2/prostaglandin E(2) production via CD44 in interleukin-1-stimulated subacromial synovial fibroblasts from patients with rotator cuff disease. J Orthop Res. 2008;26:1032–1037
  38. Wiig M, Abrahamsson SO, Lundborg G. Effects of hyaluronan on cell proliferation and collagen synthesis: a study of rabbit flexor tendons in vitro. J Hand Surg. 1996;21A:599–604
  39. Gomes JA, Amankwah R, Powell-Richards A, Dua HS. Sodium hyaluronate (hyaluronic acid) promotes migration of human corneal epithelial cells in vitro. Br J Ophthalmol. 2004;88:821–825
  40. Maniwa S, Ochi M, Motomura T, Nishikori T, Chen J, Naora H. Effects of hyaluronic acid and basic fibroblast growth factor on motility of chondrocytes and synovial cells in culture. Acta Orthop Scand. 2001;72:299–303
  41. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell. 1990;61:1303–1313

 No benefits in any form have been received or will be received related directly or indirectly to the subject of this article.

PII: S0363-5023(10)00181-4

doi: 10.1016/j.jhsa.2010.02.010

Journal of Hand Surgery
Volume 35, Issue 5 , Pages 791-796 , May 2010

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