Journal of Hand Surgery
Volume 35, Issue 4 , Pages 534-539.e1 , April 2010

Collagenase Injection as Nonsurgical Treatment of Dupuytren's Disease: 8-Year Follow-Up

  • Andrew J. Watt, MD

      Affiliations

    • Corresponding Author InformationCorresponding author: Andrew J. Watt, MD, Division of Plastic & Reconstructive Surgery, Department of Surgery, Stanford University Hospitals & Clinics, 770 Welch Road, Suite 400, Palo Alto, CA 94304
  • ,
  • Catherine M. Curtin, MD
  • ,
  • Vincent R. Hentz, MD

Received 18 November 2009 ,Accepted 6 January 2010.

References 

  1. Luck JV. Dupuytren's contracture: a new concept of the pathogenesis correlated with surgical management. J Bone Joint Surg. 1959;41A:635–664
  2. Gabbiani G, Majno G. Dupuytren's contracture: Fibroblast contraction? An ultrastructural study. Am J Path. 1972;66:31–146
  3. Tomasek JJ, Schultz RJ, Haaksma CJ. Extracellular matrix-cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren's disease. J Bone Joint Surg. 1987;69A:1400–1407
  4. Brickley-Parsons D, Glimcher MJ, Smith RJ, Albin R, Adams JP. Biochemical changes in the collagen of the palmar fascia in patients with Dupuytren's disease. J Bone Joint Surg. 1981;63A:787–797
  5. Pan D, Watson HK, Swigart C, Thomson JG, Honig SC, Narayan D. Microarray gene analysis and expression profiles of Dupuytren's contracture. Ann Plast Surg. 2003;50:618–622
  6. Lee LC, Zhang AY, Chong AK, Pham H, Longaker MT, Chang J. Expression of a novel gene, MafB, in Dupuytren's disease. J Hand Surg. 2006;31A:211–218
  7. Tonkin MA, Burke FD, Varian JP. Dupuytren's contracture: A comparative study of fasciectomy and dermofasciectomy in one hundred patients. J Hand Surg. 1984;9B:156–162
  8. Foucher G, Medina J, Malizos K. Percutaneous needle fasciotomy in Dupuytren's disease. Tech Hand Up Extrem Surg. 2001;5:161–164
  9. Bryan AS, Ghorbal MS. The long-term results of closed palmar fasciotomy in the management of Dupuytren's contracture. J Hand Surg. 1988;13B:254–256
  10. Rodrigo JJ, Neibauer JJ, Brown RL, Doyle JR. Treatment of Dupuytren's contracture: long-term results after fasciotomy and fascial excision. J Bone Joint Surg. 1976;58A:380–387
  11. McFarlane RM. Patterns of diseased fascia in the fingers of Dupuytren's contracture: displacement of the neurovascular bundle. Plast Reconstr Surg. 1974;54:31–44
  12. Coert JH, Nerin JP, Meek MF. Results of partial fasciectomy for Dupuytren's disease in 261 consecutive patients. Ann Plast Surg. 2006;57:7–13
  13. Starkweather KD, Lattuga S, Hurst LC, Badalamente MA, Guilak F, Sampson SP, et al. Collagenase in the treatment of Dupuytren's disease: an in vitro study. J Hand Surg. 1996;21A:490–495
  14. Badalamente MA, Hurst LC, Hentz VR, Hotchkiss RN, Kaplan TD, Meals RA, et al. Collagen as a clinical target: nonoperative treatment of Dupuytren's disease. J Hand Surg. 2002;27A:788–798
  15. Hurst LC, Badalamente MA, Hentz VR, et al. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. N Eng J Med. 2009;361:968–979
  16. Cools H, Verstreken J. The open palm technique in the treatment of Dupuytren's disease. Acta Orthop Belg. 1994;60:413–420
  17. Ebskov LB, Boeckstyns ME, Sorensen AI, Huagegaard M. Day care surgery for advances Duputren's contracture. J Hand Surg. 1997;22B:191–192
  18. Makela EA, Jaroma H, Harju A, Anttila S, Vainio J. Dupuytren's contracture: the long-term results after day surgery. J Hand Surg. 1991;16B:272–274
  19. Robins RH, Scott TD, Griffiths DP. Day care surgery for Dupuytren's contracture. J Hand Surg. 1993;18B:494–498
  20. Falter E, Herndl E, Mulbauer W. Dupuytren's contracture: when operate? Conservative preliminary treatment? [in German]. Fortschr Med. 1991;109:223–226
  21. Keilholz L, Seegenschmeidt MH, Sauer R. Radiotherapy for prevention of disease progression in early-stage Dupuytren's contracture: Initial and long-term results. Int J Radiat Oncol Biol Phys. 1996;36:891–897
  22. Stiles PJ. Ultrasonic therapy in Dupuytren's contracture. J Bone Joint Surg. 1966;48B:452–454
  23. Vuopala U, Kaipainen WJ. DMOS in the treatment of Dupuytren's contracture: a therapeutic experiment. Acta Rheumatol Scand. 1971;17:61–62
  24. Weinzierl G, Flugel M, Geldmacher J. Lack of effectiveness of alternative nonsurgical treatment procedures of Dupuytren contracture [in German]. Chirurg. 1993;64:492–494
  25. Kirk JE, Cheiffi M. Tocopherol administration to patients with Dupuytren's contracture: effect on plasma tocopherol levels and degree of contracture. Proc Soc Exp Biol Med. 1952;80:565–568
  26. Dahmen G, Kerckhoff F. Possibilities and limitations of the conservative treatment of Dupuytren's contracture [in German]. Med Monatsschr. 1966;20:297–300
  27. Howard L, Pratt D, Bunnell S. The use of compound F (hydrocortisone) in operative and nonoperative conditions of the hand. J Bone Joint Surg. 1953;35A:994–1002
  28. Dominguez-Malagon HR, Alferian-Ruiz A, Chavarria-Xi-cotencatl P, Duran-Hernandez MS. Clinical and cellular effects of colchicine in fibromatosis. Cancer. 1992;69:2478–2483
  29. Pittet B, Rubia-Brandt L, Desmouliere A, Roggero P, Guerret S, Grimaud JA, et al. Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study. Plast Reconstr Surg. 1994;93:1224–1235
  30. Bassot J. Treatment of Dupuytren's disease by isolated pharmacodynamic “exeresis” or “exeresis” completed by a solely cutaneous plastic step [in French]. Lille Chir. 1965;20:38–44
  31. Hueston JT. Enzymic fasciotomy. Hand. 1971;3:38–40
  32. McCarthy DM. The long-term results of enzymic fasciotomy. J Hand Surg. 1992;17B:356
  33. Badalamente MA, Hurst LC. Efficacy and safety of injectable mixed collagenase subtypes in the treatment of Dupuytren's contracture. J Hand Surg. 2007;32A:767–774

 C.M.C. received compensation for participation in the phase III clinical trial of injectable collagenase.

 Institutional funding of phase III clinical trials provided by Auxilium. No funding was received by the authors or the institution for the completion of this study. The authors have no financial interest in injectable collagenase or Auxilium. No benefits in any form have been received or will be received related directly or indirectly to the subject of this article.

PII: S0363-5023(10)00004-3

doi: 10.1016/j.jhsa.2010.01.003

Journal of Hand Surgery
Volume 35, Issue 4 , Pages 534-539.e1 , April 2010